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OraRez W (PVM/MA – Diacid)

CAS: [25153-40-6]

(methyl vinyl ether/maleic acid copolymer)

25153-40-6 Good Supplier In China

OraRez W (CAS number 25153-40-6) is a pharmaceutical-grade powder and a co-polymer of methyl vinyl ether and maleic anhydride. This versatile compound exhibits several properties making it valuable for various applications:

Mucosal Adhesive Properties: OraRez W serves as an excellent choice for mucosal delivery systems and buccal adhesives due to its adhesive nature.

Film Former: Acting as a film former, OraRez W can create protective coatings and films.

Biocompatible: OraRez W is a water-soluble film former that is biocompatible, ensuring its compatibility with biological systems.

Mucoadhesive: OraRez W PVM demonstrates mucoadhesive properties, enabling it to form complexes, solubilize, and retain active substances on mucosal tissue.

Available in different forms, such as OraRez W-100P (powder) and OraRez W-20L20 (20% water solution), OraRez W is a free acid of the copolymer with the molecular formula (C4H4O4)x.(C3H6O)x. It not only functions as a mucoadhesive capable of complexing and solubilizing actives on mucosal tissue but also forms protective films on teeth surfaces, resisting erosion from saliva and acidic beverages. OraRez W, with its diverse properties and forms, finds applications in pharmaceutical and oral care formulations.

 Properties:

o Biocompatible water-soluble film former

o Excellent bioadhesive/mucoadhesive properties

o Excellent chelating properties

o Enhances solubilization and retention of actives and drugs

o Broad molecular weight range and tunable rheology

o Polyanion having two distinct pKa’s

Applications:

OraRez W is an outstanding mucoadhesiving showing the ability to complex, solubilize and retain actives on the mucosal tissue. The material’s bioadhesive properties’ and unique structure makes it an invaluable component to pharmaceutical products. Applications include:

o Retention of drugs on mucosal tissue

o Water-soluble, pain-free adhesive applications (e.g. ostomy bags, buccal patches)

o Solubilization/retention of actives in the oral cavity

o PVM/MA-polymer or PVM/MA-drug complex systems for controlled release

o Enteric coatings and systems

o Hydrogel dressing